Abstract | BACKGROUND: DESIGN: Cross-sectional observational study. METHODS: Males with STEMI (n = 70, age 57.1 ± 7.8 years) or with stable angina ( n=30, age 59.9 ± 8.4 years) were enrolled. Angiographic MVO (angio-MVO) was defined as final TIMI flow 2 or final TIMI flow 3 with MBG ≤ 2 while electrocardiographic MVO (ECG-MVO) as a ST-segment resolution <70% at 90 minutes post-pPCI. Variables associated with STEMI and MVO were assessed among clinical, angiographic and laboratory data including testosterone (T) and insulin-like factor 3 (INSL-3), a marker of Leydig cells function. Hypotestosteronemia was defined as T<2.50 ng/ml with INSL-3<305.5 pg/ml. RESULTS: Hypotestosteronemia was detected in 32 (45.7%) STEMI patients and in 4 (13.3%) SA patients (p=0.003). STEMI patients presenting with angio-MVO were more frequently hypotestosteronemic as compared with those without (60.9% vs 38.3%, p=0.043). Hypotestosteronemia prevalence was higher among STEMI patients presenting with ECG-MVO as compared with those without (69.0% vs 31.7%, p=0.003). At multivariate analysis hypotestosteronemia independently predicted both angio-MVO (OR=4.47, 95% CI 1.30-15.36, p=0.018) and ECG-MVO (OR=7.56, 95% CI 2.20-25.99, p=0.001). CONCLUSIONS: Our study shows higher prevelence of hypotestosteronemia among STEMI patients as compared with SA patients and among STEMI patients with MVO as compared with those without, thus suggesting a possible role of T deficiency in coronary instability and MVO pathogenesis.
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Authors | Giampaolo Niccoli, Domenico Milardi, Domenico D'Amario, Francesco Fracassi, Giuseppe Grande, Roberta Antonazzo Panico, Marco Roberto, Alessandro Mandurino Mirizzi, Giulia Canu, Laura De Marinis, Cinzia Carrozza, Alfredo Pontecorvi, Filippo Crea |
Journal | European journal of preventive cardiology
(Eur J Prev Cardiol)
Vol. 22
Issue 7
Pg. 855-63
(Jul 2015)
ISSN: 2047-4881 [Electronic] England |
PMID | 24821730
(Publication Type: Comparative Study, Journal Article, Observational Study)
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Copyright | © The European Society of Cardiology 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav. |
Chemical References |
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Topics |
- Aged
- Angina, Stable
(blood, diagnosis, epidemiology, physiopathology)
- Biomarkers
(blood)
- Chi-Square Distribution
- Coronary Angiography
- Coronary Circulation
- Cross-Sectional Studies
- Electrocardiography
- Humans
- Italy
(epidemiology)
- Logistic Models
- Male
- Microcirculation
- Middle Aged
- Multivariate Analysis
- Myocardial Infarction
(blood, diagnosis, epidemiology, physiopathology)
- Odds Ratio
- Prevalence
- Prospective Studies
- Risk Factors
- Testosterone
(blood, deficiency)
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