Screening, management and surveillance for the sessile serrated adenomas/polyps.

Abstract

The incidence and mortality rates from right-sided colorectal cancers (CRCs) have not decreased, compared with the significant reduction of CRCs in the left colon in recent years. It is likely that a significant proportion of right-sided CRCs evolve from undetected sessile serrated adenomas/polyps (SSA/Ps) in the primary colonoscopy. Increasing evidences suggest that SSA/Ps are high-risk lesions, with 15% of the SSA/P patients developing subsequent CRCs or adenomas with high-grade dysplasia. However, there are many issues in the screening, management and surveillance of SSA/Ps. Based on new evidences, this review addresses major issues in the diagnostic criteria for the serrated polyps of the colorectum, new endoscopic techniques (high-resolution magnifying endoscopy, narrow-band imaging, autofluorescence imaging, confocal laser endoscopy, and endocytoscopy) for the realtime identification of SSA/Ps, and the management of SSA/Ps by endoscopic mucosal resection, endoscopic sub-mucosal dissection or surgical resection in practice.

• Authors: Xiangsheng Fu, Ye Qiu, Yali Zhang
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 7 Issue 4 Pg. 1275-85 ( 2014) ISSN: 1936-2625 [Electronic] United States
• PMID: 24817924 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Topics

• Adenoma (diagnosis, epidemiology, surgery)
• Colon (pathology, surgery)
• Colonic Polyps (diagnosis, epidemiology, surgery)
• Colorectal Surgery
• Disease Management
• Early Detection of Cancer (methods)
• Endoscopy, Gastrointestinal
• Epidemiological Monitoring
• Humans
• Incidence