Abstract | OBJECTIVES: DESIGN: Retrospective analysis of data from the Extracorporeal Life Support Organization data registry (1998 through 2013). We computed the survival to hospital discharge for neonates (age < 30 d) who required extracorporeal membrane oxygenation after stage 1 palliation and evaluated factors associated with mortality using multivariate logistic regression analysis. SETTING: PATIENTS: INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: There were 307 extracorporeal membrane oxygenation runs in the setting of extracorporeal membrane oxygenation-assisted cardiopulmonary resuscitation in 293 neonates with hypoplastic left heart syndrome following stage 1 palliation operation. The median age at cannulation was 9 days (interquartile range, 5-14 d). Survival to hospital discharge was 36%. In univariate analysis, gestational age, weight, extracorporeal membrane oxygenation duration, presence of air embolism, hemorrhagic complications, renal failure, and pulmonary complications (pulmonary hemorrhage and pneumothorax) were all associated with nonsurvival. In multivariate analysis, lower body weight at cannulation (odds ratio, 3.9; 95% CI, 1.9-8.3), duration of the extracorporeal membrane oxygenation (odds ratio, 3.4; 95% CI, 1.9-7.3), and renal failure while on extracorporeal membrane oxygenation (odds ratio, 2; 95% CI, 1.2-3.5) increased odds of mortality. CONCLUSIONS:
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Authors | Matthew Jolley, Vamsi V Yarlagadda, Satish K Rajagopal, Melvin C Almodovar, Peter T Rycus, Ravi R Thiagarajan |
Journal | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
(Pediatr Crit Care Med)
Vol. 15
Issue 6
Pg. 538-45
(Jul 2014)
ISSN: 1529-7535 [Print] United States |
PMID | 24797720
(Publication Type: Journal Article, Multicenter Study)
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Topics |
- Acute Kidney Injury
(mortality)
- Body Weight
- Cardiopulmonary Resuscitation
(methods)
- Extracorporeal Membrane Oxygenation
- Female
- Hospital Mortality
- Humans
- Hypoplastic Left Heart Syndrome
(mortality, surgery)
- Infant, Newborn
- Male
- Palliative Care
- Registries
- Retrospective Studies
- Survival Rate
- Time Factors
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