Abstract | BACKGROUND AND AIM: An increase in circulating concentrations of gastrin or gastrin precursors such as progastrin and glycine-extended gastrin has been proposed to promote the development of colorectal carcinomas (CRC). The aim of this study was to investigate whether or not circulating gastrin concentrations were increased in patients with an increased risk of developing CRC. METHOD: RESULTS: CONCLUSION: Concentrations of gastrin precursors are increased in particular groups with an increased risk of developing CRC.
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Authors | Adrienne C Paterson, Finlay A Macrae, Cathy Pizzey, Graham S Baldwin, Arthur Shulkes |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 29
Issue 3
Pg. 480-6
(Mar 2014)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 24716212
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Gastrins
- Protein Precursors
- big gastrin
- preprogastrin
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Topics |
- Adenomatous Polyposis Coli
(blood, complications, diagnosis)
- Adult
- Biomarkers, Tumor
(blood)
- Colorectal Neoplasms
(diagnosis, etiology)
- Female
- Gastrins
(blood)
- Humans
- Male
- Middle Aged
- Protein Precursors
(blood)
- Radioimmunoassay
- Risk
- Risk Assessment
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