Abstract | BACKGROUND: Our earlier studies had shown that monocrotophos (MCP), an organophosphorus insecticide (OPI), has the propensity to augment the secondary complications associated with type-1 diabetes. The present study investigates whether rats exposed for prolonged periods to monocrotophos would develop insulin resistance mediated by alteration in glucose homeostasis. METHODS: Male rats were administered sublethal doses of monocrotophos daily for 180 days. Interim blood samples were collected to measure alteration in blood glucose and lipid profile. Rats were also subjected to glucose and insulin tolerance test and fasting blood glucose and insulin levels were measured to calculate insulin resistance by HOMA-IR method. After 180 days, the rats were also evaluated for pancreatic histology and activities of hepatic gluconeogenetic enzymes. RESULTS: CONCLUSION:
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Authors | Raju Nagaraju, Apurva Kumar Ramesh Joshi, Padmanabhan Sharda Rajini |
Journal | Journal of diabetes
(J Diabetes)
Vol. 7
Issue 1
Pg. 47-59
(Jan 2015)
ISSN: 1753-0407 [Electronic] Australia |
PMID | 24698518
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd. |
Chemical References |
- Blood Glucose
- Insecticides
- Lipids
- Monocrotophos
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Topics |
- Animals
- Blood Glucose
(analysis)
- Glucose Intolerance
(chemically induced)
- Hyperglycemia
(chemically induced)
- Hyperinsulinism
(chemically induced)
- Insecticides
(toxicity)
- Insulin Resistance
- Islets of Langerhans
(cytology, drug effects)
- Lipids
(analysis)
- Male
- Monocrotophos
(toxicity)
- Rats
- Rats, Wistar
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