Over-expression of miR-98 in FFPE tissues might serve as a valuable source for biomarker discovery in breast cancer patients.
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| Abstract |
The miR-98 is thought to be associated with various cancers. This study was to evaluate the potential predictive value of miR-98 expression in formalin-fixed paraffin-embedded tissue of breast cancer patients. The expression levels of miR-98 were examined in 98 breast cancer patients and 40 cancer-free controls using real-time quantitative PCR. The comparison of miR-98 expression levels between patient and control was performed using the Mann-Whitney test. The miR-98 showed higher expression levels in breast cancer patients compared with cancer free controls (p<0.01). The expression levels of miR-98 were highly correlated with miR24/93/378 in breast cancer patients. The miR-98 exhibited great capability of discriminating between cancer patients and controls by the Receiver-operator characteristic (ROC) curve analysis. The miR-98 was found highly correlated with breast cancer by Univariable logistic regression analysis. These results suggest that over-expression of miR-98 in formalin-fixed paraffin-embedded tissues might serve as a valuable source for biomarker discovery in breast cancer patients.
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| Authors | Zhao-Qun Deng, Jia-Yu Yin, Qin Tang, Feng-Qiong Liu, Jun Qian, Jiang Lin, Rui Shao, Ming Zhang, Li He |
| Journal | International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 7 Issue 3 Pg. 1166-71 ( 2014) ISSN: 1936-2625 [Electronic] United States |
| PMID | 24696733 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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