Abstract | BACKGROUND: METHODS: C57Bl6/J male control and diabetic mice were treated with the peroxynitrite decomposition catalyst Fe(III) tetramesitylporphyrin octasulfonate ( FeTMPS, 10 mg/kg/day) or protein nitration inhibitor (-)- epicatechin gallate (20 mg/kg/day) for 4 weeks, after an initial 28 weeks of hyperglycaemia. RESULTS: Untreated diabetic mice developed motor and sensory nerve conduction velocity deficits, thermal and mechanical hypoalgesia, tactile allodynia and loss of intraepidermal nerve fibres. Both FeTMPS and epicatechin gallate partially corrected sensory nerve conduction slowing and small sensory nerve fibre dysfunction without alleviation of hyperglycaemia. Correction of motor nerve conduction deficit and increase in intraepidermal nerve fibre density were found with FeTMPS treatment only. CONCLUSIONS:
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Authors | Roman Stavniichuk, Hanna Shevalye, Sergey Lupachyk, Alexander Obrosov, John T Groves, Irina G Obrosova, Mark A Yorek |
Journal | Diabetes/metabolism research and reviews
(Diabetes Metab Res Rev)
Vol. 30
Issue 8
Pg. 669-78
(Nov 2014)
ISSN: 1520-7560 [Electronic] England |
PMID | 24687457
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Published in 2014. This article is a U.S. Government work and is in the public domain in the USA. |
Chemical References |
- 5,10,15,20-tetrakis(2,4,6-trimethyl-3,3-disulfonatophenyl)porphyrinato iron(III)
- Antioxidants
- Ferric Compounds
- Metalloporphyrins
- Nerve Tissue Proteins
- Peroxynitrous Acid
- Catechin
- epicatechin gallate
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Topics |
- Animals
- Antioxidants
(adverse effects, therapeutic use)
- Behavior, Animal
(drug effects)
- Catechin
(adverse effects, analogs & derivatives, therapeutic use)
- Diabetes Mellitus, Type 1
(complications, drug therapy)
- Diabetic Neuropathies
(metabolism, pathology, physiopathology, prevention & control)
- Epidermis
(drug effects, innervation, metabolism, pathology)
- Ferric Compounds
(adverse effects, therapeutic use)
- Ganglia, Spinal
(drug effects, metabolism, pathology)
- Male
- Metalloporphyrins
(adverse effects, therapeutic use)
- Mice, Inbred C57BL
- Motor Neurons
(drug effects, metabolism, pathology)
- Nerve Tissue Proteins
(metabolism)
- Neural Conduction
(drug effects)
- Oxidative Stress
(drug effects)
- Peripheral Nervous System
(drug effects, metabolism, pathology, physiopathology)
- Peroxynitrous Acid
(antagonists & inhibitors, metabolism)
- Reaction Time
(drug effects)
- Sensory Receptor Cells
(drug effects, metabolism, pathology)
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