Association of plasma thioredoxin-1 with renal tubular damage and cardiac prognosis in patients with chronic heart failure.

Abstract

BACKGROUND:

Thioredoxin-1 (Trx-1) is an abundant 12.5 kDa redox protein expressed in almost all eukaryotic cells that protect against the development of heart failure and kidney dysfunction. Plasma Trx-1 levels are considered as a reliable marker for oxidative stress. However, it remains to be determined whether plasma Trx-1 levels can predict cardiac prognosis in patients with chronic heart failure (CHF).

METHODS AND RESULTS:

We measured plasma Trx-1 levels and urinary β2-microglobulin-creatinine ratio (UBCR), a marker for renal tubular damage, in 156 consecutive patients with CHF and 17 control subjects. The patients were prospectively followed for a median follow-up period of 627 days and 46 cardiac events were observed. The patients with cardiac events had significantly higher plasma Trx-1 levels and UBCR levels than the cardiac event-free patients. Multivariate Cox proportional hazard analysis revealed that an elevated Trx-1 level was independently associated with poor outcome in patients with CHF after adjustment for confounding factors (hazard ratio, 1.74; 95% confidence interval, 1.33-2.29; p < 0.0001). UBCR was increased with higher plasma Trx-1 levels. Kaplan-Meier analysis demonstrated that the highest Trx-1 tertile was associated with the highest risk of cardiac events.

CONCLUSION:

Plasma Trx-1 level was associated with renal tubular damage and cardiac prognosis, suggesting that it could be a useful marker to identify patients at high risk for comorbid heart failure and renal tubular damage.

• Authors: Yoichiro Otaki, Tetsu Watanabe, Hiroki Takahashi, Shinpei Kadowaki, Taro Narumi, Yuki Honda, Masahiro Wanezaki, Shintaro Sasaki, Harutoshi Tamura, Satoshi Nishiyama, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Isao Kubota
• Journal: Journal of cardiology (J Cardiol) Vol. 64 Issue 5 Pg. 353-9 (Nov 2014) ISSN: 1876-4738 [Electronic] Netherlands
• PMID: 24685687 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers
• Thioredoxins

Topics

• Aged
• Biomarkers (blood)
• Chronic Disease
• Comorbidity
• Female
• Follow-Up Studies
• Heart Failure (diagnosis, epidemiology)
• Humans
• Kidney Diseases (diagnosis, epidemiology)
• Kidney Tubules
• Male
• Middle Aged
• Oxidative Stress
• Predictive Value of Tests
• Prognosis
• Risk
• Thioredoxins (blood, physiology)
• Time Factors