Janus kinase inhibitors and allogeneic stem cell transplantation for myelofibrosis.

Abstract

Myelofibrosis (MF) is a manifestation of several disorders of hematopoiesis, collectively referred to as myeloproliferative neoplasms. Allogeneic hematopoietic stem cell transplantation (ASCT) is the only therapy with proven curative potential. However, most patients with MF are in their 6th or 7th decade of life, and only some of these patients have been considered suitable transplantation candidates. The development of reduced-intensity conditioning regimens with limited toxicity has allowed clinicians to offer ASCT to a growing number of older patients. The availability of Janus Kinase (JAK) 1/2 inhibitors allows clinicians to provide symptom relief and improved quality of life for MF patients. These drugs may also affect the decision regarding, in particular, the timing of ASCT. Future studies need to address the role of JAK1/2 inhibitors in patients who are transplantation candidates and determine their role before and, possibly, after transplantation. The identification of indications for the use of JAK1/2 inhibitors in the context of transplantation may lead to new therapeutic strategies for patients with MF.

• Authors: Vikas Gupta, Jason Gotlib, Jerald P Radich, Nicolaus M Kröger, Damiano Rondelli, Srdan Verstovsek, H Joachim Deeg
• Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (Biol Blood Marrow Transplant) Vol. 20 Issue 9 Pg. 1274-81 (Sep 2014) ISSN: 1523-6536 [Electronic] United States
• PMID: 24680977 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2014 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Chemical References

• Janus Kinases

Topics

• Hematopoietic Stem Cell Transplantation (methods)
• Humans
• Janus Kinases (antagonists & inhibitors, metabolism)
• Primary Myelofibrosis (therapy)
• Transplantation Conditioning (methods)
• Transplantation, Homologous (methods)