Abstract | BACKGROUND: This study evaluated the usefulness of sublobar resection for patients with clinical stage IA lung adenocarcinoma that met our proposed node-negative criteria: solid tumor size of less than 0.8 cm on high-resolution computed tomography or maximum standardized uptake value of less than 1.5 on [18F]-fluoro- 2-deoxy-d-glucose positron emission tomography/computed tomography. METHODS: A multicenter database of 618 patients with completely resected clinical stage IA lung adenocarcinoma who underwent preoperative high-resolution computed tomography and [18F]-fluoro- 2-deoxy-d-glucose positron emission tomography/computed tomography was used to evaluate the surgical results of sublobar resection for patients who met our node-negative criteria. RESULTS: No patient who met the node-negative criteria had any pathological lymph node metastasis. Recurrence-free survival (RFS) and overall survival (OS) rates at 5 years were significantly higher for patients who met the node-negative criteria (RFS: 96.6%; OS: 95.9%) than for patients who did not (RFS: 75.5%, p<0.0001; OS: 83.1%, p<0.0001). Among patients who met the node-negative criteria, RFS and OS rates at 5 years were not significantly different between those who underwent lobectomy (RFS: 96.0%; OS: 95.9%) and those who underwent sublobar resection (RFS: 97.2%, p=0.94; OS: 95.9%, p=0.98). Of 264 patients with T1b (2-cm to 3-cm) tumors, 106 (40.2%) met the node-negative criteria. CONCLUSIONS: Sublobar resection without systematic nodal dissection is feasible for clinical stage IA lung adenocarcinoma that meets the above-mentioned node-negative criteria. Even a T1b tumor, which is generally unsuitable for intentional sublobar resection, can be a candidate for sublobar resection if it meets these node-negative criteria.
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Authors | Yasuhiro Tsutani, Yoshihiro Miyata, Haruhiko Nakayama, Sakae Okumura, Shuji Adachi, Masahiro Yoshimura, Morihito Okada |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 97
Issue 5
Pg. 1701-7
(May 2014)
ISSN: 1552-6259 [Electronic] Netherlands |
PMID | 24679941
(Publication Type: Comparative Study, Journal Article, Multicenter Study)
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Copyright | Copyright © 2014 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adenocarcinoma
(diagnosis, mortality, surgery)
- Adult
- Aged
- Aged, 80 and over
- Cohort Studies
- Databases, Factual
- Disease-Free Survival
- Female
- Fluorodeoxyglucose F18
- Follow-Up Studies
- Humans
- Kaplan-Meier Estimate
- Lung Neoplasms
(diagnosis, mortality, surgery)
- Lymph Nodes
(pathology)
- Male
- Middle Aged
- Multimodal Imaging
- Multivariate Analysis
- Neoplasm Invasiveness
(pathology)
- Neoplasm Staging
- Pneumonectomy
(methods, mortality)
- Positron-Emission Tomography
(methods)
- Preoperative Care
(methods)
- Proportional Hazards Models
- Retrospective Studies
- Survival Analysis
- Tomography, X-Ray Computed
(methods)
- Treatment Outcome
- Tumor Burden
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