Abstract | BACKGROUND: METHODS: Using both medical subheadings and free terms, we searched PubMed, Embase and the Institute for Scientific Information Web of Science for all eligible studies published before Nov. 2013. We retrieved 1674 citations, determining that 15 met the selection criteria. We used the odds ratio (OR) and hazard ratio (HR) as the common measures of association to quantitatively determine the correlation between cyclin D1 overexpression and outcomes of oral cancer. We performed a meta-analysis and heterogeneity, sensitivity, and subgroup analyses to clarify and validate the pooled results. RESULTS: The pooled results provided compelling evidence that cyclin D1 overexpression was significantly correlated with increased tumor size (OR = 1.617, 95% confidence interval [CI] = 1.046-2.498, p = 0.031), lymphoid node metastasis (OR = 2.035, 95% CI = 1.572-2.635, p<0.001), tumor differentiation (OR = 1.976, 95% CI = 1.363-2.866, p<0.001), and advancement of clinical stages (OR = 1.516, 95% CI = 1.140-2.015, p = 0.004), and adversely influenced overall survival of OSCC patients (HR = 1.897, 95% CI = 1.577-2.282, p<0.001). The strength of association varied in different oral cavity subsites. CONCLUSION:
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Authors | Yanhui Zhao, Dedong Yu, Handong Li, Ping Nie, Yun Zhu, Shengwen Liu, Min Zhu, Bing Fang |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 3
Pg. e93210
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24675814
(Publication Type: Journal Article, Meta-Analysis)
|
Chemical References |
- Biomarkers, Tumor
- Cyclin D1
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Topics |
- Asian People
- Biomarkers, Tumor
- Carcinoma, Squamous Cell
(genetics, mortality, pathology)
- Cyclin D1
(genetics)
- Gene Expression
- Humans
- Lymphatic Metastasis
- Mouth Neoplasms
(genetics, mortality, pathology)
- Neoplasm Staging
- Odds Ratio
- Prognosis
- Publication Bias
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