Abstract | BACKGROUND AND OBJECTIVES: The aim of this study is to determine whether the hyperproliferative and hyperkeratotic characters of cholesteatoma are associated with differentiation of keratinocytes in cholesteatoma by examining the localization of marker proteins, such as involucrin, filaggrin, and cytokeratins. MATERIALS AND METHODS: Immunohistochemical study was carried out in 30 cholesteatoma tissues and 10 retroauricular skins to examine the expression of involucrin, filaggrin, cytokeratin 4, 10 and 16. The staining results were graded as negative, weakly positive (<10%), moderately positive (10-70%), and strongly positive (>70%). RESULTS: CONCLUSIONS: It can be suggested that early differentiation of suprabasal layer may lead to hyperdifferentiation and hyperkeratosis. Different expression of cytokeratins possibly indicates the altered differentiation of cholesteatoma.
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Authors | Hyun Jung Min, Chul Won Park, Jin Hyeok Jeong, Seok Hyun Cho, Kyung Rae Kim, Seung Hwan Lee |
Journal | Korean journal of audiology
(Korean J Audiol)
Vol. 16
Issue 3
Pg. 124-9
(Dec 2012)
ISSN: 2092-9862 [Print] Korea (South) |
PMID | 24653886
(Publication Type: Journal Article)
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