Abstract | BACKGROUND: Diffusive sodium removal has been recommended to control hypertension in hemodialysis patients. Recent evidence on hospitalizations and mortality, however, challenged the benefit of lower dialysate sodium prescriptions and ignited a debate in the dialysis community. We therefore studied the relationship between dialysate sodium and blood pressure over the longer term. METHODS: We used multiply adjusted linear mixed models to estimate the association between dialysate sodium and predialysis systolic blood pressure (SBP) as well as change in SBP (delta SBP; postdialysis minus predialysis) in 23,962 patients from the international Dialysis Outcomes and Practice Patterns Study. RESULTS: We found that 43% of hemodialysis facilities had variable (individualized) dialysate sodium prescriptions (125-155 mEq/L), whereas 57% had uniform dialysate sodium prescriptions (135-145 mEq/L) for ≥90% patients. Between-group comparisons of these 2 facility types suggested that dialysate sodium, when variably prescribed, might have been used to modify predialysis SBP (P interaction = 0.01) and perhaps delta SBP levels (P interaction = 0.08). Within facilities not prone to indication bias, because dialysate sodium was not variable, higher uniform dialysate sodium (per 2 mEq/L) was associated with slightly higher SBP (+0.9 mm Hg, 95% confidence interval (CI) = 0.1-1.6 among all patients; +1.7 mm Hg, 95% CI = 0.1-3.2 among patients not treated with blood pressure medication) and no increase in delta SBP. CONCLUSIONS:
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Authors | Manfred Hecking, Angelo Karaboyas, Hugh Rayner, Rajiv Saran, Ananda Sen, Masaaki Inaba, Jürgen Bommer, Walter H Hörl, Ronald L Pisoni, Bruce M Robinson, Gere Sunder-Plassmann, Friedrich K Port |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 27
Issue 9
Pg. 1160-9
(Sep 2014)
ISSN: 1941-7225 [Electronic] United States |
PMID | 24651636
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | © American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: [email protected]. |
Chemical References |
- Antihypertensive Agents
- Dialysis Solutions
- Sodium
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Topics |
- Antihypertensive Agents
(therapeutic use)
- Blood Pressure
(drug effects)
- Dialysis Solutions
(adverse effects, therapeutic use)
- Female
- Humans
- Hypertension
(blood, diagnosis, drug therapy, epidemiology, physiopathology)
- Kidney Diseases
(blood, diagnosis, epidemiology, physiopathology, therapy)
- Linear Models
- Male
- Multivariate Analysis
- Practice Patterns, Physicians'
- Prescriptions
- Prevalence
- Prospective Studies
- Renal Dialysis
(adverse effects)
- Risk Factors
- Sodium
(adverse effects, blood, therapeutic use)
- Time Factors
- Treatment Outcome
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