Abstract | CONTEXT: AIMS: SETTINGS AND DESIGN: An open-label, parallel-group, randomized clinical trial was conducted in a tertiary care district hospital in West Bengal. MATERIALS AND METHODS: Patients presenting with features of OP poisoning were randomly allocated to receive atropine or atropine-plus- pralidoxime. Efficacy was assessed by analyzing mortality, requirement for ventilator support and the duration of stay in hospital. STATISTICAL ANALYSIS: Chi-square test was done to compare the efficacy parameters between the two groups. A two-tailed P-value <0.05 was considered as statistically significant. RESULTS: During the study period, 150 patients were screened following which 120 patients were randomized to either of the treatment arms. Add-on pralidoxime therapy did not offer any appreciable benefit over atropine alone in terms of reducing mortality (18.33% (11/60) versus 13.33% (8/60)) and ventilator requirement (5% (3/60) versus 8.33% (5/60)). However, patients randomized in the add-on pralidoxime arm experienced longer duration of hospital stay (7.02 ± 1.12 days) than those receiving atropine-alone therapy (5.68 ± 1.87 days) (P < 0.001). CONCLUSION:
|
Authors | I Banerjee, S K Tripathi, A Sinha Roy |
Journal | Journal of postgraduate medicine
(J Postgrad Med)
2014 Jan-Mar
Vol. 60
Issue 1
Pg. 27-30
ISSN: 0972-2823 [Electronic] India |
PMID | 24625936
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Antidotes
- Pralidoxime Compounds
- Atropine
- pralidoxime
|
Topics |
- Adult
- Antidotes
(administration & dosage)
- Atropine
(administration & dosage)
- Drug Therapy, Combination
- Female
- Humans
- Length of Stay
(statistics & numerical data)
- Male
- Middle Aged
- Organophosphate Poisoning
(drug therapy, mortality)
- Outcome Assessment, Health Care
- Pralidoxime Compounds
(administration & dosage)
- Time Factors
|