Cardiovascular effects of phentermine and topiramate: a new drug combination for the treatment of obesity.

Abstract	Weight loss can reduce the increased cardiovascular risk associated with obesity. Pharmacotherapy is a recognized weight loss treatment option; however, cardiovascular safety issues with some previous weight loss drugs raise concerns for newly approved pharmacotherapies. Phentermine is approved for short-term obesity treatment in conjunction with lifestyle modifications, but is commonly used chronically. Topiramate, approved for treating epilepsy and preventing migraines, also induces weight loss. A single-dose combination of low-dose phentermine and topiramate extended-release was recently approved by the United States Food and Drug Administration as an adjunct to lifestyle intervention for the chronic treatment of overweight/obese adults. This review summarizes and evaluates the cardiovascular risk/benefit profile associated with phentermine and topiramate, individually and in combination. Cardiovascular data associated with long-term use of phentermine and topiramate extended-release indicate that this combination may be a safe and effective option for reducing weight in overweight/obese patients at low-to-intermediate cardiovascular risk.
Authors	Jens Jordan, Arne Astrup, Stefan Engeli, Krzysztof Narkiewicz, Wesley W Day, Nick Finer
Journal	Journal of hypertension (J Hypertens) Vol. 32 Issue 6 Pg. 1178-88 (Jun 2014) ISSN: 1473-5598 [Electronic] England
PMID	24621808 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	Anti-Obesity Agents Appetite Depressants Drug Combinations Topiramate Fructose Phentermine
Topics	Aged Anti-Obesity Agents (administration & dosage) Appetite Depressants (administration & dosage) Cardiovascular Diseases (complications) Clinical Trials, Phase III as Topic Comorbidity Drug Combinations Female Fructose (administration & dosage, analogs & derivatives) Humans Male Middle Aged Obesity (complications, drug therapy) Overweight (complications, drug therapy) Phentermine (administration & dosage) Randomized Controlled Trials as Topic Risk Factors Topiramate Treatment Outcome Weight Loss

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