Favorable outcome with hemoperfusion of polymyxin B-immobilized fiber column for rapidly progressive interstitial pneumonia associated with clinically amyopathic dermatomyositis: report of three cases.

Abstract

We present 3 cases of rapidly progressive interstitial pneumonia (RPIP) associated with clinically amyopathic dermatomyositis (C-ADM) that were treated with two courses of direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP). Despite initial treatment with high-dose corticosteroids, pulsed cyclophosphamide, and cyclosporine, the lung disease and hypoxemia deteriorated in all the patients. After PMX-DHP treatment, the PaO2/FiO2 ratio and serum LDH and KL-6 were improved, the abnormal shadows in chest high-resolution computed tomography (HRCT) scans gradually decreased, and, finally, all patients survived. These findings indicate that PMX-DHP treatment could be effective in the management of RPIP in patients with C-ADM in combination with conventional therapy.

• Authors: Hidenori Ichiyasu, Yuko Horio, Shinsuke Tsumura, Susumu Hirosako, Yasumiko Sakamoto, Shinya Sakata, Kei Nakashima, Taiyo Komatsu, Keisuke Kojima, Aiko Masunaga, Kazuhiko Fujii, Naoki Saita, Hirotsugu Kohrogi
• Journal: Modern rheumatology (Mod Rheumatol) Vol. 24 Issue 2 Pg. 361-5 (Mar 2014) ISSN: 1439-7609 [Electronic] England
• PMID: 24593215 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Cyclosporine
• Cyclophosphamide
• Polymyxin B

Topics

• Aged
• Anti-Bacterial Agents (therapeutic use)
• Cyclophosphamide (therapeutic use)
• Cyclosporine (therapeutic use)
• Dermatomyositis (complications)
• Female
• Hemoperfusion
• Humans
• Lung Diseases, Interstitial (complications, drug therapy, therapy)
• Middle Aged
• Polymyxin B (therapeutic use)
• Treatment Outcome