Abstract | OBJECTIVE: METHODS: Serum samples were obtained from 763 patients with SSc enrolled in a multicenter Canadian cohort. The sera were analyzed by ELISA for the presence of antibodies against PM-1α. Associations between the presence of anti-PM-1α antibodies and demographic, clinical, and other serologic manifestations of SSc were investigated. RESULTS: CONCLUSION: Anti-PM-1α antibodies are relatively common in SSc and are associated with a distinct clinical phenotype, consistent with that described in association with other anti-PM/Scl autoantibodies. Although anti-PM-1α antibodies are not exclusive of other SSc-specific antibodies, they can be present in the absence thereof. Thus, anti-PM-1α antibodies may have considerable diagnostic and prognostic relevance in SSc.
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Authors | Julie D'Aoust, Marie Hudson, Solène Tatibouet, James Wick, Canadian Scleroderma Research Group, Michael Mahler, Murray Baron, Marvin J Fritzler |
Journal | Arthritis & rheumatology (Hoboken, N.J.)
(Arthritis Rheumatol)
Vol. 66
Issue 6
Pg. 1608-15
(Jun 2014)
ISSN: 2326-5205 [Electronic] United States |
PMID | 24577935
(Publication Type: Journal Article, Multicenter Study)
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Copyright | Copyright © 2014 by the American College of Rheumatology. |
Chemical References |
- Antibodies, Anti-Idiotypic
- Antibodies, Antinuclear
- Biomarkers
- Epitopes
- anticentromere antibody
- RNA Polymerase III
- Exoribonucleases
- Exosome Multienzyme Ribonuclease Complex
- EXOSC10 protein, human
- DNA Topoisomerases, Type I
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Topics |
- Adult
- Aged
- Antibodies, Anti-Idiotypic
(blood)
- Antibodies, Antinuclear
(blood)
- Biomarkers
(blood)
- Canada
(epidemiology)
- Cohort Studies
- DNA Topoisomerases, Type I
(immunology)
- Epitopes
(blood, immunology)
- Exoribonucleases
(immunology)
- Exosome Multienzyme Ribonuclease Complex
(immunology)
- Female
- Humans
- Male
- Middle Aged
- RNA Polymerase III
(immunology)
- Retrospective Studies
- Scleroderma, Systemic
(blood, epidemiology, immunology)
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