Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in a population sample of children.

Abstract

This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mites (P < 0.001), animals (P = 0.001), cockroaches (P < 0.001), and foods (P = 0.042), and furthermore, between FeNO and the number of sensitizations (all P < 0.05) or the sum of specific IgE (all P ≤ 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher FeNO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P ≤ 0.01). In conclusion, IgE sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated FeNO levels in a dose-dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways.

• Authors: T-C Yao, H-J Tsai, Y-L Tu, S-W Chang, M-C Hua, S-L Liao, M-H Tsai, C-Y Chiu, S-H Lai, K-W Yeh, J-L Huang, PATCH study group
• Journal: Allergy (Allergy) Vol. 69 Issue 5 Pg. 678-82 (May 2014) ISSN: 1398-9995 [Electronic] Denmark
• PMID: 24576320 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Allergens
• Nitric Oxide
• Immunoglobulin E

Topics

• Adolescent
• Allergens (classification, immunology)
• Animals
• Child
• Exhalation
• Female
• Humans
• Hypersensitivity (epidemiology, immunology, metabolism)
• Immunoglobulin E (blood, immunology)
• Male
• Nitric Oxide (metabolism)
• Prospective Studies