Physiological changes induced by salt intake in female Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rat, a novel obese type 2 diabetic model.

Abstract

Salt plays an important role in the control of blood pressure in obesity and diabetes mellitus. In this study, we investigated physiological changes such as blood pressure and renal function in salt-loaded female Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rats. SDT fatty rats were given 1% NaCl in drinking water for 14 weeks, from 4 to 18 weeks of age. Significant salt-sensitive hypertension was observed in the salt-loaded SDT fatty rats. Moreover, the salt-loaded rats showed a decrease of creatinine clearance and deterioration on pathological renal findings, including glomerulosclerosis and tubular and interstitial lesions. Female SDT fatty rat is a useful model for investigating the mechanisms of high salt sensitivity in obesity and diabetes mellitus.

• Authors: Yoshiaki Katsuda, Yusuke Kemmochi, Mimi Maki, Ryuhei Sano, Yukihito Ishii, Katsuhiro Miyajima, Kochi Kakimoto, Takeshi Ohta
• Journal: Animal science journal = Nihon chikusan Gakkaiho (Anim Sci J) Vol. 85 Issue 5 Pg. 588-94 (May 2014) ISSN: 1740-0929 [Electronic] Australia
• PMID: 24571912 (Publication Type: Journal Article)
• Copyright: © 2014 Japanese Society of Animal Science.

Chemical References

• Sodium Chloride
• Creatinine

Topics

• Animals
• Blood Pressure (physiology)
• Creatinine (metabolism)
• Diabetes Mellitus, Experimental (physiopathology)
• Diabetes Mellitus, Type 2 (physiopathology)
• Female
• Kidney (pathology, physiopathology)
• Obesity (physiopathology)
• Rats
• Rats, Sprague-Dawley
• Sodium Chloride (pharmacology)