Medulloblastoma in association with the Coffin-Siris syndrome.

Abstract

An 8-year old patient with Coffin-Siris syndrome is presented, who was found to have a medulloblastoma during the evaluation of apnea and ventilator dependency. Although several cases of Dandy Walker cysts and one case of brain-stem heterotopia have been described in this rare syndrome, this is the first report of medulloblastoma in a patient with Coffin-Siris syndrome. Possible pathogenetic mechanisms are briefly discussed.

• Authors: L Rogers, J Pattisapu, R R Smith, P Parker
• Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (Childs Nerv Syst) Vol. 4 Issue 1 Pg. 41-4 (Feb 1988) ISSN: 0256-7040 [Print] Germany
• PMID: 2456854 (Publication Type: Case Reports, Journal Article)

Topics

• Abnormalities, Multiple (complications)
• Brain Neoplasms (complications, diagnostic imaging, pathology)
• Child
• Cranial Fossa, Posterior
• Developmental Disabilities (complications)
• Female
• Fingers (abnormalities)
• Humans
• Intellectual Disability (complications)
• Joint Diseases (complications)
• Medulloblastoma (complications, diagnostic imaging, pathology)
• Nails, Malformed
• Radiography
• Syndrome
• Toes (abnormalities)