Abstract | PURPOSE: METHODS: Twenty-three patients with PSP and 8 patients with corticobasal degeneration according to standard diagnostic criteria underwent F-fluorodeoxyglucose (FDG) PET scans to assess disease-specific patterns of regional cerebral glucose metabolism reflecting neuronal activity. Group differences were analyzed by statistical parametric mapping and region-of-interest analyses. RESULTS: Clinically, 14 patients presented with symPSP while 9 patients were considered as hemi-PSP. Patients with symPSP or hemi-PSP showed similar bilateral medial frontal hypometabolism compared to corticobasal degeneration patients. In contrast, corticobasal degeneration patients exhibited a prominent parietal hypometabolism compared to both symPSP and hemi-PSP patients. SymPSP patients showed no significant hypometabolism compared to hemi-PSP, whereas hemi-PSP patients presented with significant hypometabolism of the motor thalamus, middle cingulate gyrus, and sensorimotor cortex contralateral to the most affected body side compared to symPSP patients. CONCLUSIONS: The present study demonstrates that a more pronounced and asymmetric involvement of cortical and subcortical motor areas is associated with a lateralized disease manifestation of PSP. Furthermore, these findings strongly suggest that FDG PET imaging may assist the challenging clinical differentiation between hemi-PSP and corticobasal degeneration by depicting disease-specific patterns of regional cerebral glucose metabolism.
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Authors | Florian Amtage, Sabine Hellwig, Annabelle Kreft, Timo Spehl, Volkmar Glauche, Christian Winkler, Michel Rijntjes, Bernhard Hellwig, Cornelius Weiller, Wolfgang A Weber, Oliver Tüscher, Philipp Tobias Meyer |
Journal | Clinical nuclear medicine
(Clin Nucl Med)
Vol. 39
Issue 4
Pg. 319-25
(Apr 2014)
ISSN: 1536-0229 [Electronic] United States |
PMID | 24566396
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Brain Mapping
- Female
- Fluorodeoxyglucose F18
- Humans
- Male
- Neurons
(diagnostic imaging, pathology)
- Positron-Emission Tomography
- Prognosis
- Supranuclear Palsy, Progressive
(diagnostic imaging, pathology, physiopathology, therapy)
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