Role of plaque calcification regulators osteoprotegerin and matrix Gla-proteins in stable angina and acute myocardial infarction.

Abstract

AIM:

To assess serum levels of the plaque calcification regulators osteoprotegerin (OPG) and Matrix Gla-proteins (MGP) in individuals with stable angina and acute myocardial infarction submitted to coronary angiography and their relation to coronary artery disease burden.

METHODS:

The study included 40 individuals affected by ST-elevation myocardial infarction (STEMI) and 40 individuals with stable angina who all underwent coronary angiography, with evaluation of the extent of coronary artery disease by Syntax Score calculation and measurement of serum OPG and MGP levels. Osteoporosis was excluded by femoral and vertebral computerized bone mineralometry.

RESULTS:

Serum OPG and MGP levels were respectively 3.87 ± 1.07 pmol/l and 6.80 ± 2.43 nmol/l in the stable angina group, 7.57 ± 1.5 pmol/l and 7.18 ± 1.93 nmol/l in the STEMI group (P < 0.01 and P = 0.33, respectively). Pearson correlation coefficient for OPG and Syntax Score, MGP and Syntax score was respectively 0.79 (P < 0.01) and 0.18 (P = 0.22) in the stable angina group, -0.03 (P = 0.43) and 0.10 (P = 0.5) in the STEMI group.Serum OPG and MGP levels were respectively 5.52 ± 1.02 pmol/l and 7.56 ± 1.42 nmol/l in diabetics, 4.3 ± 0.8 pmol/l and 6.52 ± 1.14 nmol/l in nondiabetics (P < 0.05; P < 0.05).

CONCLUSION:

OPG, in a relatively small group of patients with stable angina, correlates proportionally with the extent of coronary artery disease (CAD), as evaluated by the Syntax Score. Higher serum OPG levels can be observed in individuals with STEMI regardless of CAD burden. As for MGP, a potential role as marker of plaque calcification remains unproven.

• Authors: Alberto Margonato, Riccardo Gorla, Andrea Macchi, Fabio Buzzetti, Irene Franzoni, Maria Cristina Pedrigi, Isabella Rosa, Marcella Sirtori, Isabella Villa, Alessandro Rubinacci
• Journal: Journal of cardiovascular medicine (Hagerstown, Md.) (J Cardiovasc Med (Hagerstown)) Vol. 16 Issue 3 Pg. 156-62 (Mar 2015) ISSN: 1558-2035 [Electronic] United States
• PMID: 24566391 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biomarkers
• Calcium-Binding Proteins
• Extracellular Matrix Proteins
• Osteoprotegerin
• TNFRSF11B protein, human

Topics

• Aged
• Angina, Stable (blood, diagnostic imaging)
• Biomarkers (blood)
• Bone Density
• Calcinosis
• Calcium-Binding Proteins (blood)
• Coronary Angiography
• Coronary Artery Disease (blood, diagnostic imaging)
• Diabetic Angiopathies (blood)
• Extracellular Matrix Proteins (blood)
• Humans
• Male
• Middle Aged
• Myocardial Infarction (blood, diagnostic imaging)
• Osteoprotegerin (blood)
• Matrix Gla Protein