Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients.

Abstract

AIM:

To determine if serum pigment epithelium-derived factor (PEDF) levels in Type 2 diabetes are related to vascular risk factors and renal function.

METHODS:

PEDF was quantified by ELISA in a cross-sectional study of 857 male Veterans Affairs Diabetes Trial (VADT) subjects, and associations with cardiovascular risk factors and renal function were determined. In a subset (n=246) in whom serum was obtained early in the VADT (2.0±0.3 years post-randomization), PEDF was related to longitudinal changes in renal function over 3.1 years.

RESULTS:

Cross-sectional study: In multivariate regression models, PEDF was positively associated with serum triglycerides, waist-to-hip ratio, serum creatinine, use of ACE inhibitors or angiotensin receptor blockers, and use of lipid-lowering agents; it was negatively associated with HDL-C (all p<0.05). Longitudinal study: PEDF was not associated with changes in renal function over 3.1 years (p>0.09).

CONCLUSIONS:

Serum PEDF in Type 2 diabetic men was cross-sectionally associated with dyslipidemia, body habitus, use of common drugs for blood pressure and dyslipidemia, and indices of renal function; however, PEDF was not associated with renal decline over 3.1years.

• Authors: Alicia J Jenkins, Dongxu Fu, Madona Azar, Julie A Stoner, Derrick G Kaufman, Sarah Zhang, Richard L Klein, Maria F Lopes-Virella, Jian-Xing Ma, Timothy J Lyons, VADT investigators
• Journal: Journal of diabetes and its complications (J Diabetes Complications) 2014 May-Jun Vol. 28 Issue 3 Pg. 353-9 ISSN: 1873-460X [Electronic] United States
• PMID: 24560422 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Eye Proteins
• Nerve Growth Factors
• Serpins
• pigment epithelium-derived factor

Topics

• Aged
• Biomarkers (blood)
• Cardiovascular Diseases (epidemiology)
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (blood, complications, physiopathology)
• Diabetic Angiopathies (epidemiology)
• Dyslipidemias (blood, epidemiology)
• Eye Proteins (blood)
• Glomerular Filtration Rate (physiology)
• Humans
• Incidence
• Kidney (physiopathology)
• Longitudinal Studies
• Male
• Middle Aged
• Nerve Growth Factors (blood)
• Predictive Value of Tests
• Risk Factors
• Serpins (blood)