Worsened arterial stiffness in high-risk cardiovascular patients with high habitual carbohydrate intake: a cross-sectional vascular function study.

Abstract

BACKGROUND:

Previous studies suggested that high dietary carbohydrate intake is associated with increased cardiovascular risk through raised triglyceride and decreased high-density lipoprotein-cholesterol levels. However, the relation between carbohydrate intake and arterial stiffness has not been established. The purpose of this study was to examine this relation among high-risk cardiovascular patients.

METHODS:

We studied the relation between dietary macronutrient intake and arterial stiffness in 364 patients with documented cardiovascular diseases or risk equivalent (coronary artery diseases 62%, ischemic stroke 13%, diabetes mellitus 55%) and in 93 age-and-sex matched control subjects. Dietary macronutrient intake was assessed using a validated food-frequency questionnaire (FFQ) for Chinese. Heart-ankle pulse wave velocity (PWV) was measured non-invasively with a Vascular Profiling System (VP2000, Colin Corp. USA). A dietary pattern with ≥60% total energy intake derived from carbohydrates was defined as a high-carbohydrate diet according to the Dietary Reference Intakes (DRI) for Chinese.

RESULTS:

Subjects who consumed a high-carbohydrate diet had significantly higher mean PWV than those who did not consume a high-carbohydrate diet (P = 0.039). After adjustment for potential confounders, high-carbohydrate diet was associated with significantly increased PWV [B = 73.50 (10.81 to 136.19), P = 0.022]. However, there was no significant association between high-carbohydrate diet and PWV in controls (P = 0.634).

CONCLUSIONS:

High-carbohydrate diet is associated with increased arterial stiffness in patients with established cardiovascular disease or risk equivalent.

• Authors: Hiu-Ting Chan, Yap-Hang Chan, Kai Hang Yiu, Sheung-Wai Li, Sidney Tam, Chu-Pak Lau, Hung-Fat Tse
• Journal: BMC cardiovascular disorders (BMC Cardiovasc Disord) Vol. 14 Pg. 24 (Feb 21 2014) ISSN: 1471-2261 [Electronic] England
• PMID: 24559092 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Carbohydrates

Topics

• Aged
• Cardiovascular Diseases (diagnosis, etiology, physiopathology)
• Case-Control Studies
• China
• Cross-Sectional Studies
• Dietary Carbohydrates (adverse effects)
• Energy Intake
• Feeding Behavior
• Female
• Humans
• Male
• Middle Aged
• Nutritional Status
• Pulse Wave Analysis
• Risk Factors
• Surveys and Questionnaires
• Vascular Stiffness