Abstract | BACKGROUND & OBJECTIVES: METHODS: A total of 28 CD patients were randomized to receive GFD, calcium and cholecalciferol (group A), and zoledronic acid (group B). Baseline biochemical tests and T-score by dual energy x-ray absorptiometer were done and repeated after 12 months. RESULTS: The T-score showed improvement in the control arm (group A) from -3.31 ± 1.46 to -2.12 ± 1.44, a gain of 35.9 per cent (P<0.05) and in drug arm (group B) -2.82 ± 1.27 to -1.06 ± 1.84, registering a gain of 62.4 per cent (P<0.001). However, there was no difference in improvement of T-score in zoledronic acid group as compared to the control group. INTERPRETATION & CONCLUSIONS: Administration of zoledronic acid was not found to be better than GFD alone in increasing BMD in CD patients with low BMD in this pilot study.
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Authors | Mukul Kumar, Ashu Rastogi, Sanjay Kumar Bhadada, Anil Bhansali, Kim Vaiphei, Rakesh Kochhar |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 138
Issue 6
Pg. 882-7
(Dec 2013)
ISSN: 0971-5916 [Print] India |
PMID | 24521630
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Diphosphonates
- Imidazoles
- Cholecalciferol
- Zoledronic Acid
- Calcium
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Topics |
- Absorptiometry, Photon
- Adult
- Bone Density
(drug effects)
- Calcium
(administration & dosage)
- Celiac Disease
(drug therapy, metabolism, pathology)
- Cholecalciferol
(administration & dosage)
- Diet, Gluten-Free
- Diphosphonates
(administration & dosage)
- Female
- Humans
- Imidazoles
(administration & dosage)
- Male
- Pilot Projects
- Zoledronic Acid
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