Comparison of the effects of Mg-6Zn and Ti-3Al-2.5V alloys on TGF-β/TNF-α/VEGF/b-FGF in the healing of the intestinal tract in vivo.

Abstract

To evaluate the different effects of Mg-6Zn alloy and Ti-3Al-2.5V alloy implants in intestinal tract healing, we compared these two different alloys with respect to their effect on a rat's intestinal tract, using serum magnesium, radiology, pathology and immunohistochemistry in vivo. It was found using the scanning electron microscope that the Mg-6Zn alloy began to degrade during the first week and that the Ti-3Al-2.5V alloy was non-degradable throughout the process. The Mg-6Zn alloy did not have an impact on serum magnesium. Superior to the Ti-3Al-2.5V alloy, the Mg-6Zn alloy enhanced the expression of transforming growth factor-β1 in healing tissue, and promoted the expression of both the vascular endothelial growth factor and the basic fibroblast growth factor, which helped angiogenesis and healing. The Mg-6Zn alloy reduced the expression of the tumor necrosis factor (TNF-α) at different stages and decreased inflammatory response, which may have been related to the zinc inhibiting TNF-α. In general, the Mg-6Zn alloy performed better than Ti-3Al-2.5V at promoting healing and reducing inflammation. The Mg-6Zn alloy may be a promising candidate for use in the pins of circular staplers for gastrointestinal reconstruction in medicine.

• Authors: Jun Yan, Yigang Chen, Qingling Yuan, Xiaohu Wang, Song Yu, Wencai Qiu, Zhigang Wang, Kaixing Ai, Xiaonong Zhang, Shaoxiang Zhang, Changli Zhao, Qi Zheng
• Journal: Biomedical materials (Bristol, England) (Biomed Mater) Vol. 9 Issue 2 Pg. 025011 (Apr 2014) ISSN: 1748-605X [Electronic] England
• PMID: 24518303 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alloys
• Biocompatible Materials
• Mg-6Zn alloy
• Tgfb1 protein, rat
• Ti-3Al-2.5V alloy
• Transforming Growth Factor beta1
• Tumor Necrosis Factor-alpha
• Vascular Endothelial Growth Factor A
• vascular endothelial growth factor A, rat
• Vanadium
• Fibroblast Growth Factor 2
• Aluminum
• Titanium
• Magnesium
• Zinc

Topics

• Alloys (chemistry)
• Aluminum (chemistry)
• Animals
• Biocompatible Materials (chemistry)
• Fibroblast Growth Factor 2 (metabolism)
• Inflammation
• Intestinal Mucosa (metabolism)
• Magnesium (chemistry)
• Male
• Materials Testing
• Microscopy, Electron, Scanning
• Rats
• Rats, Sprague-Dawley
• Titanium (chemistry)
• Transforming Growth Factor beta1 (metabolism)
• Tumor Necrosis Factor-alpha (metabolism)
• Vanadium (chemistry)
• Vascular Endothelial Growth Factor A (metabolism)
• Wound Healing
• Zinc (chemistry)