Abstract | OBJECTIVE: METHODS: 25 CHD patients were randomized for treatment with ezetimibe 10 mg (group 1) or simvastatin 20 mg (group 2) with progression to ezetimibe + simvastatin 10/20 mg or simvastatin 80 mg, respectively. Kinetic studies were performed at baseline and after each treatment period of 6 weeks. The fractional catabolic rates (FCR) of the emulsion labeled with (14)C-CE and (3)H-TG, that represent respectively chylomicron remnant and triglyceride removal, were calculated. Comparisons were made by ANOVA. RESULTS: The (14)CE-FCR in group 1 were 0.005 ± 0.004, 0.011 ± 0.008 and 0.018 ± 0.005 min(-1) and in group 2 were 0.004 ± 0.003, 0.011 ± 0.008 and 0.019 ± 0.007 min(-1) respectively at baseline, after 6 and 12 weeks (p < 0.05 vs. baseline, and 6 vs. 12 weeks). The (3)H-TG-FCR in group 1 were 0.017 ± 0.011, 0.024 ± 0.011 and 0.042 ± 0.013 min(-1) and in group 2 were 0.016 ± 0.009, 0.022 ± 0.009 and 0.037 ± 0.012 min(-1) at baseline, after 6 and 12 weeks (p < 0.05 vs. baseline, and 6 vs. 12 weeks). There were no differences between groups in time. CONCLUSION: Both treatments increased similarly the removal from plasma of chylomicron and remnants in CHD patients.
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Authors | Otavio Celeste Mangili, Ana C Moron Gagliardi, Leonardo Celeste Mangili, Carlos H Mesquita, Luiz A Machado Cesar, Akira Tanaka, Ernst J Schaefer, Raul C Maranhão, Raul D Santos |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 233
Issue 1
Pg. 319-25
(Mar 2014)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 24503114
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Azetidines
- Cholesterol Esters
- Chylomicron Remnants
- Chylomicrons
- Triglycerides
- Triolein
- cholesteryl oleate
- Simvastatin
- Ezetimibe
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Topics |
- Aged
- Azetidines
(administration & dosage)
- Cholesterol Esters
(metabolism)
- Chylomicron Remnants
(metabolism)
- Chylomicrons
(blood, metabolism)
- Coronary Disease
(blood, drug therapy)
- Drug Therapy, Combination
- Ezetimibe
- Female
- Humans
- Kinetics
- Male
- Middle Aged
- Simvastatin
(administration & dosage)
- Triglycerides
(blood)
- Triolein
(metabolism)
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