Correlation of β-catenin, but not PIN1 and cyclin D1, overexpression with disease-free and overall survival in patients with cancer of the parotid gland.

Abstract

BACKGROUND:

Malignant tumors of the salivary glands comprise about 3% to 5% of all head and neck carcinomas. The purpose of our study was to find possible predictive and/or prognostic markers for parotid cancer.

METHODS:

A total of 46 tissue samples of carcinomas of the parotid gland were immunohistochemically stained for ß-catenin, cyclin D1, and PIN1. The factors were analyzed regarding their prognostic value for disease-free and overall survival.

RESULTS:

An overexpression of the cytoplasmatic ß-catenin was linked to a statistically significant worse outcome regarding disease-free (p = .0296) and overall survival (p = .0416). The 5-year overall survival was 83.9% in patients without and 0% in patients presenting with overexpression of cytoplasmatic ß-catenin. Additionally, Union Internationale Contre le Cancer (UICC) stage correlated with overall survival (p = .0306) and disease-free survival (DFS; p = .0473).

CONCLUSION:

Multivariate analysis showed that overexpression of cytoplasmatic ß-catenin and the UICC stage are 2 independent prognostic markers for survival in patients with parotid cancer.

• Authors: Claudia Lill, Sven Schneider, Rudolf Seemann, Lorenz Kadletz, Klaus Aumayr, Bahil Ghanim, Dietmar Thurnher
• Journal: Head & neck (Head Neck) Vol. 37 Issue 1 Pg. 30-6 (Jan 2015) ISSN: 1097-0347 [Electronic] United States
• PMID: 24500803 (Publication Type: Journal Article)
• Copyright: © 2014 Wiley Periodicals, Inc.

Chemical References

• NIMA-Interacting Peptidylprolyl Isomerase
• beta Catenin
• Cyclin D1
• PIN1 protein, human
• Peptidylprolyl Isomerase

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Carcinoma (metabolism, mortality, pathology)
• Cyclin D1 (metabolism)
• Disease-Free Survival
• Female
• Humans
• Male
• Middle Aged
• NIMA-Interacting Peptidylprolyl Isomerase
• Parotid Neoplasms (metabolism, mortality, pathology)
• Peptidylprolyl Isomerase (metabolism)
• Retrospective Studies
• Survival Rate
• Young Adult
• beta Catenin (metabolism)