Abstract | BACKGROUND:
Calcium-sensing receptor (CaSR) is a typical G protein coupled receptor. The rs17251221 SNP is located in an intron of the CaSR gene, and the G allele is considered a gain of function mutation. Previous studies revealed that rs17251221 polymorphisms contribute to the risk of developing certain types of cancers. This study investigated the rs17251221 SNP in breast cancer by analyzing the correlation of the rs17251221 genotype with breast cancer susceptibility, clinicopathological features and prognosis. METHODS: A TaqMan assay was used to genotype the rs17251221 SNP in a case-control study. The expression levels of CaSR in breast cancer tissues were determined using quantitative reverse-transcription PCR (qRT-PCR) and western blot analysis. The association of the rs17251221 genotype and the clinicopathological characteristics, as well as the prognosis of the breast cancer patient, was assessed statistically. RESULTS: CONCLUSION: The rs17251221 SNP is a risk factor associated with breast cancer susceptibility, as well as a prognostic indicator. Our data suggest that rs17251221 may be a potential therapeutic target in breast cancer.
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Authors | Xiaoyan Li, Xiangnan Kong, Liyu Jiang, Tingting Ma, Shi Yan, Cunzhong Yuan, Qifeng Yang |
Journal | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
(Cell Physiol Biochem)
Vol. 33
Issue 1
Pg. 165-72
( 2014)
ISSN: 1421-9778 [Electronic] Germany |
PMID | 24481145
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Calcium-Sensing
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Topics |
- Breast Neoplasms
(genetics, pathology)
- Case-Control Studies
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Kaplan-Meier Estimate
- Middle Aged
- Polymorphism, Single Nucleotide
(genetics)
- Prognosis
- Receptors, Calcium-Sensing
(genetics)
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