Expression of Ia and monocyte-macrophage lineage antigens in giant cell tumor of bone and related lesions.

Abstract

An immunohistochemical study of six giant cell tumors of bone and eight related lesions (aneurysmal bone cyst, fibrous histiocytoma, and giant cell tumor of tendon sheath) was performed using a panel of monoclonal antibodies directed to the Ia and monocyte-macrophage lineage antigens. In all types of lesion, osteoclastlike multinucleate giant cells were negative for both types of antigen, but a proportion of mononuclear cells gave positive reactions. While the possibility that these cells are reactive cannot be excluded, in giant cell tumor and malignant fibrous histiocytoma, their frequency and their morphologic similarity to the rest of the tissue suggest that they may be an intrinsic part of the neoplasm. This finding is consistent with the presumed fibrohistiocytic nature of these tumors.

• Authors: L Ling, M J Klein, H A Sissons, G C Steiner, R J Winchester
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 112 Issue 1 Pg. 65-9 (Jan 1988) ISSN: 0003-9985 [Print] United States
• PMID: 2447853 (Publication Type: Journal Article)

Chemical References

• Antigens, Differentiation
• Histocompatibility Antigens Class II
• monocyte-macrophage differentiation antigen
• Acid Phosphatase

Topics

• Acid Phosphatase (metabolism)
• Antigens, Differentiation (immunology)
• Bone Cysts (immunology)
• Bone Neoplasms (enzymology, immunology)
• Giant Cell Tumors (enzymology, immunology)
• Histiocytoma, Benign Fibrous (immunology)
• Histocompatibility Antigens Class II (immunology)
• Humans
• Immunohistochemistry
• Staining and Labeling
• Tendons