Post-transfusion hypertension and seizure in congenital hemolytic anemia: a case report and literature review.

Abstract

A rare syndrome of hypertension, seizures and intracranial bleed has been reported among patients with congenital hemolytic anemia who underwent multiple blood transfusions. We report this syndrome in a 12-year-old Malay girl with hemoglobin E-beta-thalassemia, who underwent intensive transfusion and subsequently had headache, visual loss, severe hypertension and seizures. A comprehensive literature review revealed 30 patients with this syndrome, of whom 15 had intracranial bleed and 12 among these 15 died. A less-intensive transfusion regimen among patients with chronic hemolytic anemia and prompt detection and management of hypertension may prevent this potentially fatal syndrome.

• Authors: Chin Fang Ngim, Chen Siew Ng, Nai Ming Lai
• Journal: Journal of tropical pediatrics (J Trop Pediatr) Vol. 60 Issue 3 Pg. 253-6 (Jun 2014) ISSN: 1465-3664 [Electronic] England
• PMID: 24473404 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: © The Author [2014]. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected].

Topics

• Anemia, Hemolytic, Congenital
• Cerebral Hemorrhage (etiology)
• Child
• Female
• Headache (etiology)
• Humans
• Hypertension (etiology)
• Rare Diseases
• Seizures (etiology)
• Syndrome
• Thalassemia (complications, therapy)
• Transfusion Reaction