Changes in psychiatric comorbidity during early postsurgical period in patients operated for medically refractory epilepsy--a MINI-based follow-up study.

Abstract

PURPOSE:

The purpose of this study was to assess axis-I DSM-IV psychiatric disorders in patients at baseline and 3 months after surgery for medically refractory temporal lobe epilepsy.

METHOD:

The Mini International Neuropsychiatric Interview (MINI) and Quality of Life in Epilepsy Inventory-10 (QOLIE-10) were evaluated before and 3 months after surgery in 50 consecutive patients (21 females, 29 males) with medically refractory temporal lobe epilepsy (persistent seizures>2/month, despite treatment with ≥2 appropriate drugs in adequate doses for ≥2 years) who underwent surgery [anterior temporal lobectomy with amygdalo-hippocampectomy (for mesial temporal sclerosis in 40), electrocorticography-guided lesionectomy (for other lesions in 10)].

RESULTS:

Twenty-six patients (52%) had an axis-I psychiatric disorder [26% depressive disorder, 28% anxiety disorder] at baseline, while 30 (60%) patients had an axis-I psychiatric disorder [28% depressive disorder, 28% anxiety disorder] at 3 months after surgery. Twenty percent developed a new psychiatric disorder, while 12% showed improvement postsurgery. Mean QOLIE-10 scores improved from 23.78 to 17.80 [24 (48%) patients showed ≥5-point improvement]. Thirty-four (68%) patients had no seizure, 6 (12%) had non-disabling seizures, while 2 (4%) had disabling seizures after surgery. High frequency of seizures prior to surgery (p<0.038) and seizure occurrence after surgery (p<0.055) predicted the presence of psychiatric disorders after surgery. No clinical characteristic could predict development of new psychiatric disorder after surgery.

CONCLUSION:

Psychiatric dysfunction in the early postsurgery period is seen in nearly half of patients undergoing surgery for temporal lobe epilepsy, is mild in nature, and does not adversely affect quality of life but may cause significant clinical problems when it arises de novo postsurgery.

• Authors: Soaham Desai, Garima Shukla, Vinay Goyal, Achal Srivastava, M V Padma Srivastava, Manjari Tripathi, Mamta Singh, K Shivanand, Rajesh Sagar, Aditya Gupta, P Saratchandra, Ajay Garg, C S Bal, Madhuri Behari
• Journal: Epilepsy & behavior : E&B (Epilepsy Behav) Vol. 32 Pg. 29-33 (Mar 2014) ISSN: 1525-5069 [Electronic] United States
• PMID: 24463306 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Topics

• Adult
• Anterior Temporal Lobectomy (methods)
• Comorbidity
• Diagnostic and Statistical Manual of Mental Disorders
• Electroencephalography
• Epilepsy (epidemiology, surgery)
• Epilepsy, Temporal Lobe (complications, epidemiology, surgery)
• Female
• Follow-Up Studies
• Humans
• Male
• Mental Disorders (complications, epidemiology)
• Middle Aged
• Postoperative Complications (epidemiology)
• Postoperative Period
• Quality of Life
• Seizures (epidemiology)
• Sickness Impact Profile
• Treatment Outcome
• Young Adult