Abstract | OBJECTIVES: DESIGN: Retrospective case series review SETTING: Tertiary care institution PARTICIPANTS: INTERVENTION: The medical and anesthesia records of patients with LEOPARD syndrome were reviewed. Demographic information, clinical features of LEOPARD syndrome, comorbidities, intraoperative and postoperative events and complications were recorded. A systematic literature review also was conducted. MEASUREMENTS AND MAIN RESULTS: Nine patients with LEOPARD syndrome underwent 49 procedures under general anesthesia (n = 40) or monitored anesthesia care (n = 9). The majority of operations were related to correction of cardiac anomalies (n = 20). The most common cardiac malformations were ventricular septal hypertrophy and pulmonary (or subpulmonary) stenosis, and major perioperative complications were related to severe arrhythmias and/or cardiac decompensation. CONCLUSIONS: Dominant pathology associated with perioperative complications in patients with LEOPARD syndrome is related to cardiac disease. A large proportion of patients with this condition have ventricular septal hypertrophy, which tends to progress with age; therefore, these patients undergoing anesthesia should have recent cardiologist evaluation.
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Authors | Tze Yeng Yeoh, Erica D Wittwer, Toby N Weingarten, Juraj Sprung |
Journal | Journal of cardiothoracic and vascular anesthesia
(J Cardiothorac Vasc Anesth)
Vol. 28
Issue 5
Pg. 1243-50
(Oct 2014)
ISSN: 1532-8422 [Electronic] United States |
PMID | 24461361
(Publication Type: Journal Article)
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Copyright | © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Anesthesia
(adverse effects)
- Anesthetics
(administration & dosage, adverse effects)
- Female
- Humans
- Intraoperative Complications
(chemically induced, diagnostic imaging, etiology)
- LEOPARD Syndrome
(diagnostic imaging, surgery)
- Male
- Middle Aged
- Retrospective Studies
- Ultrasonography
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