Abstract |
Production of reactive oxygen species has been used in clinical therapy for cancer treatment in a technique known as Photodynamic Therapy ( PDT). The success of this therapy depends on oxygen concentration since hypoxia limits the formation of reactive oxygen species with consequent clinical failure of PDT. Herein, a possible synergistic effect between singlet oxygen and nitric oxide (NO) is examined since this scenario may display increased tumoricidal activity. To this end, the trinuclear species [Ru(pc)(pz)2{ Ru(bpy)2(NO)}2](PF6)6 (pc = phthalocyanine; pz = pyrazine; bpy = bipyridine) was synthesized to be a combined NO and singlet oxygen photogenerator. Photobiological assays using at 4 × 10(-6) M in the B16F10 cell line result in the decrease of cell viability to 21.78 ± 0.29% of normal under light irradiation at 660 nm. However, in the dark and at the same concentration of compound , viability was 91.82 ± 0.37% of normal. The potential application of a system like in clinical therapy against cancer may be as an upgrade to normal photodynamic therapy.
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Authors | Tassiele A Heinrich, Antonio Claudio Tedesco, Jon M Fukuto, Roberto Santana da Silva |
Journal | Dalton transactions (Cambridge, England : 2003)
(Dalton Trans)
Vol. 43
Issue 10
Pg. 4021-5
(Mar 14 2014)
ISSN: 1477-9234 [Electronic] England |
PMID | 24452093
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Coordination Complexes
- Indoles
- Isoindoles
- Pyrazines
- Pyridines
- Singlet Oxygen
- Nitric Oxide
- Ruthenium
- phthalocyanine
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Topics |
- Animals
- Antineoplastic Agents
(chemistry, pharmacology, radiation effects)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Coordination Complexes
(chemistry, pharmacology, radiation effects)
- Indoles
(chemistry)
- Isoindoles
- Light
- Mice
- Neoplasms
(drug therapy)
- Nitric Oxide
(chemistry)
- Photochemotherapy
- Pyrazines
(chemistry)
- Pyridines
(chemistry)
- Ruthenium
(chemistry, pharmacology, radiation effects)
- Singlet Oxygen
(chemistry)
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