Abstract | BACKGROUND: White matter hyperintensity (WMH), a common radiographic finding associated with stroke risk and outcome, has been linked to matrix metalloproteinase ( MMP) activity and increased levels of oxidative stress in nonstroke populations. We sought to determine whether WMH severity is associated with plasma levels of MMPs and oxidative stress (F2-isoprostane) in subjects with acute ischemic stroke (AIS). METHODS: We measured plasma biomarker levels at baseline and 48 hours in consecutive AIS subjects. White matter hyperintensity volume (WMHv) was quantified on admission magnetic resonance imaging using a validated semiautomated protocol, and Spearman correlation coefficients were derived for all measured biomarkers. RESULTS: We enrolled 405 AIS subjects (mean age 70±15 years; 58% male; median WMHv 3.4 cm3, interquartile range 1.4-9.5). WMHv and age were strongly correlated (ρ=.57, P<.0001). WMHv and MMP-2 levels were correlated at baseline (ρ=.23, P<.0001) and at 48 hours poststroke (ρ=.19, P=.002). In multivariate analysis, 48-hour MMP-2 levels were independently associated with WMHv (β=.12, P=.04). MMP-9 and F2-isioprostane levels did not correlate with WMHv. CONCLUSIONS: In AIS patients, MMP-2 levels are associated with the pre-existing burden of WMH. If validated, these findings may further elucidate the role of MMP-2 in pathophysiology of chronic cerebrovascular injury, such as WMH, and in brain susceptibility to acute ischemia.
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Authors | Zachary A Corbin, Natalia S Rost, Svetlana Lorenzano, Walter N Kernan, Michael K Parides, Jeffrey B Blumberg, Paul E Milbury, Ken Arai, Sophia N Hartdegen, Eng H Lo, Steven K Feske, Karen L Furie |
Journal | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
(J Stroke Cerebrovasc Dis)
Vol. 23
Issue 6
Pg. 1300-6
(Jul 2014)
ISSN: 1532-8511 [Electronic] United States |
PMID | 24439130
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
|
Topics |
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Brain
(pathology)
- Brain Ischemia
(blood, pathology)
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Matrix Metalloproteinase 2
(blood)
- Matrix Metalloproteinase 9
(blood)
- Middle Aged
- Oxidative Stress
- Stroke
(blood, pathology)
- White Matter
(pathology)
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