Grape-seed procyanidins prevent the cafeteria-diet-induced decrease of glucagon-like peptide-1 production.

Abstract

Grape-seed procyanidin extract (GSPE) has been reported to improve insulin resistance in cafeteria rats. Because glucagon-like peptide-1 (GLP-1) is involved in glucose homeostasis, the preventive effects of GSPE on GLP-1 production, secretion, and elimination were evaluated in a model of diet-induced insulin resistance. Rats were fed a cafeteria diet for 12 weeks, and 25 mg of GSPE/kg of body weight was administered concomitantly. Vehicle-treated cafeteria-fed rats and chow-fed rats were used as controls. The cafeteria diet decreased active GLP-1 plasma levels, which is attributed to a decreased intestinal GLP-1 production, linked to reduced colonic enteroendocrine cell populations. Such effects were prevented by GSPE. In the same context, GSPE avoided the decrease on intestinal dipeptidyl-peptidase 4 (DPP4) activity and modulated the gene expression of GLP-1 and its receptor in the hypothalamus. In conclusion, the preventive treatment with GSPE abrogates the effects of the cafeteria diet on intestinal GLP-1 production and DPP4 activity.

• Authors: Noemi González-Abuín, Neus Martínez-Micaelo, Mayte Blay, Anna Ardévol, Montserrat Pinent
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 62 Issue 5 Pg. 1066-72 (Feb 05 2014) ISSN: 1520-5118 [Electronic] United States
• PMID: 24410268 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biflavonoids
• Grape Seed Extract
• Proanthocyanidins
• procyanidin
• Glucagon-Like Peptide 1
• Catechin
• Glucose

Topics

• Animals
• Biflavonoids (metabolism)
• Catechin (metabolism)
• Diet (adverse effects)
• Down-Regulation
• Female
• Glucagon-Like Peptide 1 (genetics, metabolism)
• Glucose (metabolism)
• Grape Seed Extract (metabolism)
• Humans
• Insulin Resistance
• Proanthocyanidins (metabolism)
• Rats
• Rats, Wistar
• Vitis (chemistry, metabolism)