The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells.

Abstract

Dendrogenin A (DDA) and dendrogenin B (DDB) are new aminoalkyl oxysterols which display re-differentiation of tumor cells of neuronal origin at nanomolar concentrations. We analyzed the influence of dendrogenins on adult mice neural stem cell proliferation, sphere formation and differentiation. DDA and DDB were found to have potent proliferative effects in neural stem cells. Additionally, they induce neuronal outgrowth from neurospheres during in vitro cultivation. Taken together, our results demonstrate a novel role for dendrogenins A and B in neural stem cell proliferation and differentiation which further increases their likely importance to compensate for neuronal cell loss in the brain.

• Authors: Shaden A M Khalifa, Philippe de Medina, Anna Erlandsson, Hesham R El-Seedi, Sandrine Silvente-Poirot, Marc Poirot
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 446 Issue 3 Pg. 681-6 (Apr 11 2014) ISSN: 1090-2104 [Electronic] United States
• PMID: 24406163 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• 5-hydroxy-6-(2-(1H-imidazol-4-yl)ethylamino)cholestan-3-ol
• 5-hydroxy-6-(3-(4-aminobutylamino)propylamino)cholest-7-en-3-ol
• Cholestanols
• Imidazoles
• Spermidine

Topics

• Animals
• Cell Differentiation (drug effects)
• Cell Proliferation (drug effects)
• Cells, Cultured
• Cholestanols (pharmacology)
• Female
• Imidazoles (pharmacology)
• Mice
• Mice, Inbred C57BL
• Neural Stem Cells (drug effects)
• Spermidine (analogs & derivatives, pharmacology)