Effect of atorvastatin-eluting stents in a rabbit iliac artery restenosis model.

Abstract

Statins have pleiotropic effects, which include the inhibition of neointima hyperplasia, the inhibition of vascular inflammation, and platelet inhibition. The aim of this study was to examine the effect of an atorvastatin-eluting stent (AES) in a rabbit iliac artery overstretch restenosis model. Ten rabbits were used in this study (10 rabbits, 10 iliac arteries for each stent). An AES and paclitaxel-eluting stent (PES) were implanted in the left and right iliac arteries in a rabbit (2 stents in each rabbit). The stents were deployed with oversizing (stent/artery ratio 1.3:1), and histopathologic analysis was assessed at 28 days after stenting. There were no significant differences in the injury score, lumen area, or inflammation score. There were significant differences in the neointimal area (0.7±0.18 mm(2) in the AES group vs. 0.4±0.25 mm(2) in the PES group, p<0.01), in the percentage stenosis area (14.8±5.06% in the AES group vs. 10.5±6.80% in the PES group, p<0.05), and in the fibrin score (0.4±0.51 in the AES group vs. 2.7±0.48 in the PES group, p<0.001). Although the AES did not suppress neointimal hyperplasia compared with the PES, it showed a superior arterial healing effect in a rabbit iliac artery overstretch restenosis model.

• Authors: Kyung Seob Lim, Myung Ho Jeong, In Ho Bae, Jun-Kyu Park, Dae Sung Park, Jong Min Kim, Jung Ha Kim, Dong Lyun Cho, Doo Sun Sim, Keun-Ho Park, Young Joon Hong, Youngkeun Ahn
• Journal: Chonnam medical journal (Chonnam Med J) Vol. 49 Issue 3 Pg. 118-24 (Dec 2013) ISSN: 2233-7385 [Print] Korea (South)
• PMID: 24400214 (Publication Type: Journal Article)