[A case of successful radical resection of rectal cancer with neo-adjuvant chemoradiotherapy].

Abstract

In cases of advanced rectal cancer, preoperative chemoradiotherapy( CRT) serves to improve the local control rate, survival rate, radical resection rate, and/or probability of sphincter muscle preservation. According to the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer, preoperative CRT is the standard treatment for rectal cancer in Europe and the United States. However, there is insufficient evidence in support of its efficacy and safety in Japan, and therefore, CRT needs to be evaluated in properly designed clinical trials. Recently, several studies have reported on the efficacy of preoperative CRT in Japan. Herein, we report a case of rectal cancer in which radical resection was successfully performed with neo-adjuvant CRT.

• Authors: Katsunori Ami, Yosuke Kawai, Ryota Seki, Kentaro Gokita, Shoko Takeuchi, Keiichi Fujiya, Jun Takasaki, Hidetoshi Amagasa, Hirotaka Kamikozuru, Hideaki Ganno, Kenichiro Imai, Akira Fukuda, Takeshi Nagahama, Masayuki Ando, Youichi Okada, Shikofumi Tei, Kuniyoshi Arai
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 12 Pg. 1987-9 (Nov 2013) ISSN: 0385-0684 [Print] Japan
• PMID: 24393988 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Organoplatinum Compounds
• Leucovorin
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Chemoradiotherapy
• Fluorouracil (administration & dosage)
• Humans
• Leucovorin (administration & dosage)
• Male
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Staging
• Organoplatinum Compounds (administration & dosage)
• Rectal Neoplasms (therapy)
• Recurrence
• Treatment Outcome