Effects of postoperative chemotherapy and radiotherapy on patients with squamous cell carcinoma of the oral cavity and multiple regional lymph node metastases.

Abstract	Nodal metastasis in oral squamous cell carcinoma (OSCC) is considered to be a predictor of a poor prognosis. The aim of this study was to investigate the relationship between the number of positive lymph nodes and the prognosis in OSCC patients with nodal metastases and to assess the effects of postoperative radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) on this patient group. A retrospective investigation of 98 patients with OSCC who underwent radical neck dissection and had at least three pathologically positive lymph nodes was performed. The 5-year disease-specific survival rate was 66.7% for patients with 3 positive nodes, while it was significantly lower for those with 4 positive nodes and those with ≥ 5 positive nodes (21.5% and 46.1%, respectively; P < 0.01). The loco-regional control and disease-specific survival rates for the surgery alone, surgery plus RT, and surgery plus CCRT groups were 46.2% and 40.5%, 66.3% and 54.4%, and 81.7% and 52.4%, respectively. For patients with ≥ 4 positive nodes, the loco-regional control rate after surgery plus CCRT was better than that observed after surgery alone (77.5% vs. 32.6%, P = 0.01). Postoperative RT and CCRT have positive impacts on the prognosis of OSCC patients with advanced stage neck disease.
Authors	H Takahashi, S Yanamoto, S Yamada, M Umeda, T Shigeta, T Minamikawa, Y Shibuya, T Komori, T Shiraishi, I Asahina, S Yokoo, S Ri
Journal	International journal of oral and maxillofacial surgery (Int J Oral Maxillofac Surg) Vol. 43 Issue 6 Pg. 680-5 (Jun 2014) ISSN: 1399-0020 [Electronic] Denmark
PMID	24387949 (Publication Type: Journal Article)
Copyright	Copyright © 2013 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Chemical References	Antineoplastic Agents
Topics	Adult Aged Aged, 80 and over Antineoplastic Agents (therapeutic use) Carcinoma, Squamous Cell (pathology, secondary, therapy) Chemoradiotherapy Combined Modality Therapy Diagnostic Imaging Female Humans Lymphatic Metastasis Male Middle Aged Mouth Neoplasms (pathology, therapy) Neck Dissection Neoplasm Staging Postoperative Care Prognosis Retrospective Studies Treatment Outcome

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