Treatment of first-attack genital herpes--acyclovir versus inosine pranobex.

Abstract

77 patients with a first attack of genital herpes were entered into a double-blind trial to compare the efficacy of acyclovir with that of inosine pranobex. 24 patients received acyclovir with that of inosine pranobex, and 28 both drugs. Patients treated with acyclovir or both drugs healed more quickly and had a shorter duration of viral shedding than those treated with inosine pranobex. The time to first recurrence and frequency of subsequent recurrences were similar in the three treatment groups. Acyclovir is the treatment of choice for patients with a first attack of genital herpes.

• Authors: A Mindel, G Kinghorn, E Allason-Jones, P Woolley, I Barton, A Faherty, M Jeavons, P Williams, G Patou
• Journal: Lancet (London, England) (Lancet) Vol. 1 Issue 8543 Pg. 1171-3 (May 23 1987) ISSN: 0140-6736 [Print] England
• PMID: 2437417 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Inosine
• Inosine Pranobex
• Acyclovir

Topics

• Acyclovir (therapeutic use)
• Adult
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Herpes Genitalis (drug therapy, microbiology)
• Humans
• Inosine (analogs & derivatives)
• Inosine Pranobex (therapeutic use)
• Male
• Random Allocation
• Recurrence
• Simplexvirus (isolation & purification)
• Time Factors