Apolipoprotein M and the risk of unprovoked recurrent venous thromboembolism.

Abstract

INTRODUCTION:

Apolipoprotein M (ApoM) protects against atherosclerosis; however, it is unknown whether it also protects against recurrent venous thromboembolism (VTE).

MATERIAL AND METHODS:

Patients in the Malmö Thrombophilia Study (MATS) were followed post-anticoagulant treatment until the diagnosis of recurrent VTE or the end of the study (mean follow-up 36 months). Among patients with a first episode of unprovoked VTE, we identified 43 patients (9.7%) with recurrent VTE during the follow-up period. Three age- and sex-matched control subjects without recurrent VTE were selected for each case (n = 129). Plasma levels of ApoM were quantified by a sandwich ELISA method.

RESULTS:

Among all patients, the plasma levels (mean ± SD) of ApoM were not significantly different between patients with recurrent (0.70 ± 0.2) and non-recurrent VTE (0.74 ± 0.2), p = 0.2. However, after stratification of data according to gender, male patients with recurrent VTE showed significantly (p=0.02) lower ApoM levels (0.63 ± 0.2) as compared to those with non-recurrent VTE (0.74 ± 0.2). No significant differences in ApoM levels were found between recurrent (0.8 ± 0.2) and non-recurrent VTE (0.75 ± 0.2) in female patients, p = 0.3. Cox-regression analysis showed that the risk of recurrent VTE was 0.98 (95% CI, 0.96-0.99) for each 0.01 μM increase in ApoM level in male patients (p = 0.042), and this risk remained unchanged after adjusting for inherited thrombophilia and body mass index (p = 0.027). ApoM levels were not associated with the risk of recurrent VTE in female patients.

CONCLUSION:

Our results show that levels of ApoM in recurrent VTE may differ according to gender and lower levels of ApoM may predict VTE recurrence in male patients.

• Authors: Ashfaque A Memon, Jan Sundquist, Bengt Zöller, Xiao Wang, Björn Dahlbäck, Peter J Svensson, Kristina Sundquist
• Journal: Thrombosis research (Thromb Res) Vol. 133 Issue 3 Pg. 322-6 (Mar 2014) ISSN: 1879-2472 [Electronic] United States
• PMID: 24359967 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• APOM protein, human
• Anticoagulants
• Apolipoproteins
• Apolipoproteins M
• Lipocalins

Topics

• Anticoagulants (administration & dosage)
• Apolipoproteins (blood)
• Apolipoproteins M
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Lipocalins (blood)
• Male
• Middle Aged
• Recurrence
• Risk Factors
• Sex Factors
• Venous Thromboembolism (blood, pathology)