Evaluation of the antipsychotic effects of 2-(dimethylamino)- and 2-(methylamino)-7H-naphtho[1,2,3-de]quinolin-7-one derivatives in experimental model of psychosis in mice.

Abstract

Research into novel therapeutic strategies for schizophrenia with high efficacy and low side effects has been progressed in recent years. In the present study, anti-schizophrenia activities of 2-(dimethylamino)- and 2-(methylamino)- 7H-naphtho[1,2,3-de]quinolin-7-one derivatives (D1-D10) have been evaluated in ketamine-induced experimental schizophrenia model in mice. For this aim, experimental animals was submitted to ketamine intraperitoneal injection at 100 mg/kg/day. Then, D1-D10 were administrated intra-cerebroventricularly to mice and in next step, animals depressive-like behaviors have been examined by despair swimming test. The obtained results demonstrate that 7H-naphtho[1,2,3- de]quinolin-7-one derivatives, specifically D9, reduced depressive-like behaviors via the decrease of the immobility time and the increase of the swim and climb times. Overall, these results showed that these alkaloids have anti-schizophrenia efficacy and due to their low side effects, they can be used as a new strategy for the treatment of depressive symptoms of schizophrenia patients.

• Authors: Akbar Hajizadeh Moghaddam, Eduardo Sobarzo-Sánchez, Seyed Fazel Nabavi, Maria Daglia, Seyed Mohammad Nabavi
• Journal: Current topics in medicinal chemistry (Curr Top Med Chem) Vol. 14 Issue 2 Pg. 229-33 ( 2014) ISSN: 1873-4294 [Electronic] United Arab Emirates
• PMID: 24359198 (Publication Type: Journal Article)

Chemical References

• Antipsychotic Agents
• Aporphines
• Naphthoquinones
• Ketamine

Topics

• Animals
• Antipsychotic Agents (chemistry, pharmacology)
• Aporphines (chemistry, pharmacology)
• Disease Models, Animal
• Ketamine (toxicity)
• Male
• Mice
• Naphthoquinones (chemistry)
• Psychotic Disorders (drug therapy, etiology)
• Schizophrenia (chemically induced, drug therapy)
• Swimming