Osteoporotic fracture healing: potential use of medicinal plants from the tropics.

Abstract

With improvements in living standards and healthcare, life expectancy has been increasing dramatically in most parts of the world. These situations lead to the increase in the reported cases of geriatrics-related diseases such as hypogonadal osteoporosis with skeletal fracture being the ultimate outcome, which eventually causes significant morbidity and mortality. The deficient gonadal hormones, which are the main cause of hypogonadal osteoporosis, could be substituted with hormone replacement therapy to hinder bone loss. However, the artificial hormonal therapy has been linked to grievous conditions such as breast and prostate cancers. In view of the various adverse effects associated with conventional treatment, many researchers are now focusing on finding alternative remedies from nature. This article explores the possibilities of certain medicinal plants native to Malaysia that possess androgenic and antioxidant properties to potentially be used in the treatment of fracture due to osteoporosis in ageing people.

• Authors: Mohd Azri Abdul Jalil, Ahmad Nazrun Shuid, Norliza Muhammad
• Journal: Current drug targets (Curr Drug Targets) Vol. 14 Issue 14 Pg. 1651-8 (Dec 2013) ISSN: 1873-5592 [Electronic] United Arab Emirates
• PMID: 24354586 (Publication Type: Journal Article, Review)

Chemical References

• Antioxidants
• Plant Preparations

Topics

• Animals
• Antioxidants (administration & dosage, therapeutic use)
• Fracture Healing (drug effects)
• Fractures, Bone (drug therapy, etiology, metabolism)
• Hormone Replacement Therapy
• Humans
• Malaysia
• Medicine, East Asian Traditional
• Osteoporosis (complications, drug therapy, metabolism)
• Oxidative Stress (drug effects)
• Plant Preparations (administration & dosage, therapeutic use)
• Plants, Medicinal