Small bowel transglutaminase 2-specific IgA deposits in dermatitis herpetiformis.

Abstract	Dermatitis herpetiformis (DH) is an extraintestinal manifestation of coeliac disease. Untreated coeliac disease patients are known to have transglutaminase 2 (TG2)-targeted IgA deposits in the small bowel mucosa. To evaluate whether similar intestinal IgA deposits are also present in DH and whether the deposits disappear with gluten-free diet, 47 untreated and 27 treated DH patients were studied. Seventy-nine percent of untreated and 41% of the treated DH patients had TG2-specific IgA deposits in the small bowel, and the presence of the deposits showed a significant association with the degree of small bowel villous atrophy (p < 0.001). Other coeliac-disease related inflammatory markers were also investigated, and the density of small bowel mucosal intraepithelial γδ(+) T cells was increased in 91% of untreated and 73% of treated DH patients. The results show that the majority of untreated DH patients have similar gluten-dependent TG2-specific IgA deposits the small bowel mucosa as coeliac disease patients.
Authors	Teea T Salmi, Kaisa Hervonen, Kaija Laurila, Pekka Collin, Markku Mäki, Outi Koskinen, Heini Huhtala, Katri Kaukinen, Timo Reunala
Journal	Acta dermato-venereologica (Acta Derm Venereol) Vol. 94 Issue 4 Pg. 393-7 (Jul 2014) ISSN: 1651-2057 [Electronic] Sweden
PMID	24352382 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Autoantibodies Biomarkers Immunoglobulin A Protein Glutamine gamma Glutamyltransferase 2 Transglutaminases GTP-Binding Proteins
Topics	Adolescent Adult Aged Atrophy Autoantibodies (analysis) Autoimmunity Biomarkers (analysis) Celiac Disease (complications, diagnosis, diet therapy, enzymology, immunology) Dermatitis Herpetiformis (diagnosis, enzymology, immunology) Diet, Gluten-Free Female GTP-Binding Proteins Humans Immunoglobulin A (analysis) Intestinal Mucosa (enzymology, immunology, pathology) Intestine, Small (enzymology, immunology, pathology) Male Middle Aged Protein Glutamine gamma Glutamyltransferase 2 Transglutaminases (immunology) Treatment Outcome Young Adult

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