Abstract | SUMMARY: OBJECTIVE: METHODS: The study participants were 25 consecutive hypertensive patients (8 females, 17 males; 65 ± 10 years). Insulin resistance was defined as a patient showing ≥2.5 in the homeostasis model assessment (HOMA) index. We divided subjects into non- insulin resistance (n = 10) and insulin resistance groups (n = 15) based on the HOMA index. Telmisartan was administered (40 mg/day) was administered for 24 weeks. RESULTS: In the insulin resistance group, telmisartan treatment resulted in a significant decrease in the HOMA index and serum level of C-reactive protein, and it increased the serum level of adiponectin (P < 0.05, respectively). Such improvements were not observed in the non- insulin resistance group. Stepwise multiple regression analysis showed that the increase in the serum level of adiponectin was independently associated with reduction in the HOMA index. CONCLUSIONS:
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Authors | Tetsuji Shinohara, Naohiko Takahashi, Ichitaro Abe, Norihiro Okada, Osamu Wakisaka, Kunio Yufu, Masahide Hara, Mikiko Nakagawa, Tetsunori Saikawa, Hironobu Yoshimatsu |
Journal | Obesity research & clinical practice
(Obes Res Clin Pract)
2011 Oct-Dec
Vol. 5
Issue 4
Pg. e267-360
ISSN: 1871-403X [Print] Netherlands |
PMID | 24331136
(Publication Type: Journal Article)
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Copyright | © 2011 Asian Oceanian Association for the Study of Obesity . Published by Elsevier Ltd. All rights reserved. |