Total adiponectin, but not inflammatory markers C-reactive protein, tumor necrosis factor-α, interluekin-6 and monocyte chemoattractant protein-1, correlates with increasing glucose intolerance in pregnant Chinese-Americans.

Abstract

BACKGROUND:

Elevated insulin, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 levels and decreased high molecular weight adiponectin (HMW-APN) levels have been reported in Caucasians with gestational diabetes mellitus (GDM). No similar studies have been performed in Chinese women.

METHODS:

Serum samples were obtained 1 h after a 50-g glucose challenge test (1HGCT) from Chinese-American women at 24-28 gestational weeks and total adiponectin (T-APN), HMW-APN, CRP, TNF-α, IL-6, and MCP-1 concentrations were measured. Correlation coefficients for glucose (1HGCT), HbA1c, insulin, and body mass index (BMI) were calculated against T-APN, HMW-APN, CRP, TNF-α, IL-6, and MCP-1. Significant P-values were determined using Bonferroni adjustments.

RESULTS:

Women with GDM had higher insulin and 1HGCT and lower T-APN. In addition, T-APN was lower in non-GDM subjects who had 1HGCT ≥135 mg/dL with no abnormal or one abnormal glucose value on the 3-h oral glucose tolerance test. There were no significant differences in HMW-APN and inflammatory marker levels between non-GDM and GDM groups. There were negative correlations between T-APN and 1HGCT, insulin, BMI, and HbA1c, as well as between HMW-APN and 1HGCT, insulin, and BMI. No significant correlations were observed between 1HGCT, HbA1c, insulin, or BMI and CRP, TNF-α, IL-6, or MCP-1.

CONCLUSIONS:

T-APN is reduced in Chinese women with GDM and those without GDM but with evidence of glucose intolerance. Unlike results reported for Caucasians, Chinese-American women with GDM do not exhibit elevated levels of CRP, TNF-α, IL-6, or MCP-1, possibly because Chinese women are relatively leaner compared with Caucasians.

• Authors: So-Young Kim, Vanessa Sy, Takako Araki, Nicole Babushkin, Diana Huang, Doris Tan, Emilia Liao, George Liu, Stephen Wan, Leonid Poretsky, Donna Seto-Young
• Journal: Journal of diabetes (J Diabetes) Vol. 6 Issue 4 Pg. 360-8 (Jul 2014) ISSN: 1753-0407 [Electronic] Australia
• PMID: 24330072 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

Chemical References

• Adiponectin
• Biomarkers
• Blood Glucose
• CCL2 protein, human
• Chemokine CCL2
• Glycated Hemoglobin A
• Interleukin-6
• Tumor Necrosis Factor-alpha
• C-Reactive Protein

Topics

• Adiponectin (blood)
• Adolescent
• Adult
• Asian
• Biomarkers (blood)
• Blood Glucose (analysis)
• C-Reactive Protein (metabolism)
• Chemokine CCL2 (blood)
• Diabetes, Gestational (blood, diagnosis)
• Enzyme-Linked Immunosorbent Assay
• Female
• Follow-Up Studies
• Glucose Intolerance (blood, diagnosis)
• Glycated Hemoglobin (analysis)
• Humans
• Interleukin-6 (blood)
• Pregnancy
• Prognosis
• Tumor Necrosis Factor-alpha (blood)
• Young Adult