Abstract | BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of pancreatic cysts obtains cyst fluid for cytologic and biochemical analysis, which may determine whether the cyst is mucinous and malignant, contributing to patient management. Despite this added value, EUS-FNA remains controversial in the preoperative assessment of pancreatic cysts. The objective of this study was to assess the utility of EUS-FNA in a cohort of small pancreatic cysts that were benign on imaging studies. METHODS: All pancreatic cysts that underwent initial EUS-FNA in 2006 and 2007 were retrospectively analyzed. Ninety-two patients with pancreatic cysts met the inclusion criteria. Patients who had high-risk or worrisome features on imaging studies were excluded. Cytology, histology, and cyst fluid analysis data were collected. The main outcome measurements were radiologic and clinical follow-up as well as cytopathologic and histologic results. RESULTS: EUS-FNA supported a diagnosis of a mucinous cyst in 38 of 92 patients (41%) by carcinoembryonic antigen (CEA) measurement and/or cytology. Cytology demonstrated an absence of high-grade atypia (HGA) in 89 of 92 patients (97%). The mean follow-up was 4.4 years (range, 0-7.7 years), during which 6 cysts were surgically resected and 16 cysts were resampled by at least 1 subsequent EUS-FNA. The overall negative predictive value of cytologic examination for HGA was 99%. CONCLUSIONS: EUS-FNA is a screening test that contributes to a triple-negative test for pancreatic cysts--no high-risk stigmata, no worrisome features, and no HGA on cytology--providing a negative predictive value of 99% for conservative management.
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Authors | Roseann I Wu, Won Jae Yoon, William R Brugge, Mari Mino-Kenudson, Martha B Pitman |
Journal | Cancer cytopathology
(Cancer Cytopathol)
Vol. 122
Issue 6
Pg. 412-9
(Jun 2014)
ISSN: 1934-6638 [Electronic] United States |
PMID | 24327575
(Publication Type: Journal Article)
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Copyright | © 2013 American Cancer Society. |
Chemical References |
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Topics |
- Carcinoembryonic Antigen
(analysis)
- Cyst Fluid
(chemistry, diagnostic imaging)
- Cystadenocarcinoma, Mucinous
(diagnostic imaging, pathology)
- Endoscopic Ultrasound-Guided Fine Needle Aspiration
- Follow-Up Studies
- Humans
- Mass Screening
(methods)
- Pancreatic Cyst
(diagnostic imaging, pathology)
- Pancreatic Neoplasms
(diagnostic imaging, pathology)
- Retrospective Studies
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