[Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in penile cancer].

Abstract

OBJECTIVE:

To investigate the expression of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) in penile cancer.

METHODS:

A total of 96 patients with penile cancer were included, the expression of TS and DPD in tumor tissues were examined by immunohistochemistry method, the relationship of TS and DPD expressions with the clinical characters were also analyzed.

RESULTS:

The expression of TS and DPD in penile cancer tissue were 41. 67% (40/96) and 33. 33% (32/96) respectively. There was a positive correlation between TS and DPD expression (Pearson C= 0. 362, P<0. 01). DPD was found to be more expressed in non-smoking patients (P = 0. 040).

CONCLUSION:

TS and DPD were moderately expressed in penile cancer and their expressions were positively correlated. This could be helpful for the application of fluorouracil in chemotherapy for the patients with penile cancer.

• Authors: Feng Zhao, Jie Tang, Hong-Feng Gou, Long-Hao Li, Hang Dong, Ye Chen, Ke Cheng, Jing Ding, Xin Chen, Hai-Tao Men, Ji-Yan Liu
• Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 44 Issue 5 Pg. 756-9 (Sep 2013) ISSN: 1672-173X [Print] China
• PMID: 24325106 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dihydrouracil Dehydrogenase (NADP)
• Thymidylate Synthase
• Fluorouracil

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Squamous Cell (enzymology)
• Dihydrouracil Dehydrogenase (NADP) (metabolism)
• Fluorouracil (therapeutic use)
• Humans
• Male
• Middle Aged
• Penile Neoplasms (enzymology)
• Thymidylate Synthase (metabolism)