Motor-dominant polyneuropathy due to IgM monoclonal antibody against disialosyl gangliosides in a patient with mantle cell lymphoma.

Abstract

A rapidly progressive motor-dominant neuropathy associated with IgM monoclonal antibody against gangliosides with disialosyl residues, GD3, GD1b, GT1b, and GQ1b, in a 60-year-old Japanese man with mantle cell lymphoma is reported. Plasma exchange and chemotherapy for mantle cell lymphoma were performed for the neuropathy and mantle cell lymphoma. After therapy, the motor neuropathy dramatically improved concurrently with substantial reduction of the antibody activities especially in reaction to GD1b. This is the first case report of neuropathy with anti-disialosyl IgM antibodies associated with mantle cell lymphoma, and plasma exchange and chemotherapy were effective.

• Authors: Akio Mori, Yuji Ueno, Takuma Kuroki, Yasunobu Hoshino, Hideki Shimura, Yasunobu Sekiguchi, Masaaki Noguchi, Yukihiro Hamada, Susumu Kusunoki, Nobutaka Hattori, Takao Urabe
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 337 Issue 1-2 Pg. 215-8 (Feb 15 2014) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 24315580 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Antigens, CD
• Immunoglobulin M

Topics

• Antigens, CD (immunology)
• Humans
• Immunoglobulin M (blood)
• Lymphoma, Mantle-Cell (blood, complications, immunology)
• Male
• Middle Aged
• Polyneuropathies (etiology)
• Tomography Scanners, X-Ray Computed